Mansoura University, Egypt
Title: 25-Hydroxyvitamin D Status Correlation with Male Hypogonadism Among Type 2 Diabetic Patients
Mohamed M. Aboelnaga, M.D A Graduate of Mansoura faculty of medicine, Egypt, Nov 2000. Trained in endocrinology unit at the Mansoura university general hospital and specialized medical hospital, Egypt during residency period from 2002 till Feb 20006. Received Master degree in internal medicine ( Endocrinology and diabetes) from Mansoura faculty of medicine in May 2005, and M.D degree in internal medicine ( Endocrinology and diabetes) from Mansoura faculty of medicine in May 2011. Recently, in Dec 2016, promoted to assistant professor of endocrinology and diabetes at Mansoura faculty of medicine. Published researches in thyroid disorders, Parathyroid disorder, Pituitary gland disorders, vitamin D relation to endocrinal disorders, diabetes mellitus, male hypogonadism, PCOD and others endocrinology disorders.
Background and objective: Several studies reported correlation between hypogonadism and vitamin D deficiency. But most of these studies investigated hypergonadotropic hypogonadism patients. Hypogonadism complicating diabetes was predominately hypogonadotropic reflecting pituitary dysfunction. We evaluated the relationship between vitamin D status with testosterone and gonadotropin deficiency among patients T2DM, Also we aimed to determine the risk factor for male hypogonadism among those patients. Methodology: We enrolled 95 male T2DM patients in this cross-sectional study. Vitamin D insufficiency was settled as 25(OH) D level < 30 ng/mL while deficiency < 20 ng/ml.
Result: Testosterone deficiency prevalence in T2DM patients was 41.1% and hypogondotopic hypogonadism prevalence was 87.2 %. T2DM patients with hypogonadism had significant lower 25(OH)D levels than patients without hypogonadism. T2DM patients with testosterone deficiency had significant higher prevalence of vitamin D deficiency (61.5 % and 28.6 %), and non-significant higher prevalence of insufficiency (84.6 % and 82.1 %) in comparison with patients withouthypogonadism. Vitamin D deficient T2DM patients showed significant lower total testosterone levels, on the other hand Vitamin D deficient diabetic patients showed non-significant lower gonadotropin as compared to those without deficiency. In linear regression analysis, we found that 25(OH)D was a significant predictor of total testosterone levels among T2DM patients.In logistic regression analysis, vitamin D deficiency but not insuficiency was a significant risk factor for male hypogonadism among T2DM patients.
All previous results showed a postive correlation between vitamin D and testosterone levels but not gonadotropin. Conclusion: Diabetic patients with testosterone deficiency had significant lower 25(OH)D levels and higher prevalence of vitamin D deficiency and insufficiency as compared to those without testosterone deficiency. Vitamin D deficient patients had lower testosterone levels but not gondotopin. 25(OH)D was a significant predictor of total testosterone levels. Vitamin D deficiency was a significant risk factor for male hypogonadism in among T2DM patients.