Adrenal Insufficiency and Adrenal Crisis

Adrenal crisis is a life-threatening exacerbation of adrenal insufficiency due to increased physiologic demand (infection) or decreased supply (discontinuation of steroid therapy) of cortisol. It usually occurs in response to a major stress, such as acute myocardial infarction, sepsis, surgery, major injury, trauma, or other illnesses in any patient with primary or secondary adrenal insufficiency. In this situation, the adrenal gland fails to mount a stress response via increasing circulating cortisol levels. The most frequent iatrogenic cause of acute adrenal crisis is rapid withdrawal of steroids in patients with adrenal atrophy secondary to long-term steroid administration.

  • Track 1-1 Primary adrenal insufficiency, or Addison disease
  • Track 2-2 Secondary adrenal insufficiency
  • Track 3-3 Acute adrenal failure
  • Track 4-4 Addisonian crisis

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